JWH-018

JWH-018: Overview

Full Name:
1-Pentyl-3-(1-naphthoyl)indole

Classification:
Synthetic cannabinoid (designer drug)

Origin:
JWH-018 was developed by chemist John W. Huffman in the mid-1990s during research into cannabinoid receptors. The “JWH” in its name reflects his initials.

Chemical Profile

• Formula: C₂₄H₂₃NO

• Molar Mass: 341.45 g/mol

• Form: Often found as a white powder or dissolved into herbal mixtures (“spice”, “K2”)

Effects

JWH-018 acts as a full agonist at CB1 and CB2 receptors, meaning it can produce stronger effects than natural THC. Commonly reported effects include:

• Euphoria

• Altered perception

• Increased heart rate

• Anxiety or paranoia

• Hallucinations

• Vomiting

• Short-term memory impairment

Risks and Warnings

• Toxicity: JWH-018 has been linked to seizures, psychosis, and cardiovascular events.

• Dependence: Regular use may lead to withdrawal symptoms similar to cannabis but potentially more severe.

• Overdose: Effects can be unpredictable due to high potency and variability in synthetic blends.